An Efficient Method for the Large-Scale Synthesis of Atorvastatin Calcium
نویسندگان
چکیده
منابع مشابه
nano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
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BACKGROUND If literature protocols are followed, conversion of an advanced ketal ester intermediate (available in kilogram quantities via a published Paal-Knorr synthesis) to cholesterol-lowering drug atorvastatin calcium is hampered by several process issues, particularly at the final stage where the hemi-calcium salt is obtained. RESULTS We developed a high-yielding synthesis of atorvastati...
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ژورنال
عنوان ژورنال: Biomolecules and Therapeutics
سال: 2008
ISSN: 1976-9148
DOI: 10.4062/biomolther.2008.16.1.028